Ablynx

Ablynx is a biopharmaceutical company focused on the discovery and development of Nanobodies®, a novel class of therapeutic proteins based on single-domain antibody fragments, for a range of serious and life-threatening human diseases. The Company, with Headquarters in Ghent, Belgium, began operations in 2001 and currently employs over 200 employees. Ablynx is developing a portfolio of Nanobody®-based therapeutic programmes in a number of major disease areas, including inflammation, thrombosis, oncology and Alzheimer’s disease. Ablynx has ongoing research collaborations and significant partnerships with several major pharmaceutical companies, including Boehringer Ingelheim, Wyeth Pharmaceuticals, Novartis and P&G Pharma.

(Senior) Research Associate, Selection team

We are looking for a motivated senior research associate to join the team responsible for the isolation and screening of Nanobodies® from variant libraries using phage and yeast surface display technologies.

 

Responsibilities:

  • Generation of Nanobody libraries and selection of Nanobody candidates via phage and yeast surface display
  • Application of molecular biology techniques including DNA/RNA preparation, PCR, analytical and preparative DNA restriction, cloning and transformation of bacteria and yeast (electroporation)
  • Screening for target-specific Nanobodies via ELISA- and FACS-based methods
  • Working with mammalian cell lines
  • Performing data analysis and interpretation; assisting in experimental design
  • Preparation of written reports of experimental results in English
  • Supporting project teams with in-depth Nanobody selection strategy knowledge
  • As an active member of several project teams, you will be required to work effectively in a matrix structure and communicate results at team and project meetings

 

Requirements:

  • Minimum of 5 years of relevant work experience
  • Degree of Professional Bachelor in Laboratory Technology or Biotechnology (Laboratory Technician A1), Bachelor or Master in Industrial Sciences (Industrial Engineer), Biochemistry, Biotechnology or equivalent
  • Expertise in molecular biology techniques as well as in handling and analysis of recombinant proteins
  • Prior experience with Display technologies (phage, yeast, ribosomal, etc.) is a plus
  • Proficiency in MS Office
  • Solid analytical and problem-solving skills; attention to quality, accuracy and detail
  • Team player, sense of initiative, enthusiastic and self-motivated
  • Excellent communication skills are essential – fluency in English (spoken and written) is expected

 

The CV of the applicant should include a paragraph specifying the technical expertise.


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