Ablynx is a biopharmaceutical company focused on the discovery and development of Nanobodies®, a novel class of therapeutic proteins based on single-domain antibody fragments, for a range of serious and life-threatening human diseases. The Company, with Headquarters in Ghent, Belgium, began operations in 2001 and currently employs over 200 employees. Ablynx is developing a portfolio of Nanobody®-based therapeutic programmes in a number of major disease areas, including inflammation, thrombosis, oncology and Alzheimer’s disease. Ablynx has ongoing research collaborations and significant partnerships with several major pharmaceutical companies, including Boehringer Ingelheim, Wyeth Pharmaceuticals, Novartis and P&G Pharma.

(Jr) Research Associate Downstream process development - TEMP 1 YEAR

Job Description

The DownStream Process (DSP) Development team (~ 20 people) within the Chemistry Manufacturing and Control (CMC) Pharmaceutical Development & Technology Department at Ablynx is looking for a (Jr) Research Associate who will be part of the team responsible for:

  • Generic purifications to deliver CMC grade Nanobody batches for all projects running in Ablynx
  • Development of DSP processes for Nanobody® Development Candidates during pre-clinical development
  • Large-scale DSP activities (purification of tens to thousands of grams), including in-house production of non-GMP DS for toxicology studies
  • DSP-related activities to support late-stage projects (e.g. PAR studies and process validation).
  • DSP platform improvement and new Technology exploration



    • Uses state-of-the-art equipment and different types of chromatography (affinity, IEX, HIC, mixed mode) and filtration (µ-filtration and ultrafiltration TFF, depth filtration) techniques to perform generic purifications in a timely manner with eye for quality
    • Reports about the results and progress to the line manager
    • Prepares experimental reports (eLN) and meeting summaries/presentations


The candidate should:

  • Have degree B. Sc., M. Sc. (Industrial Engineer), Master in Biochemistry/ Biotechnology or equivalent
  • Have a hands-on mentality
  • Have excellent communication skills (fluent in English, written and spoken)
  • Have knowledge of Word, Powerpoint and Excel
  • Have good organizational skills
  • Have sense for initiative, quality and accuracy
  • Have the ability and desire to work in a fast-paced, dynamic environment
  • Be a team player, enthusiastic and flexible


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