Ablynx

Ablynx is a biopharmaceutical company engaged in the development of Nanobodies®, proprietary therapeutic proteins based on single-domain antibody fragments, which combine the advantages of conventional antibody drugs with some of the features of small-molecule drugs. Ablynx is dedicated to creating new medicines which will make a real difference to society. Today, the Company has approximately 40 proprietary and partnered programmes in development in various therapeutic areas including inflammation, haematology, immuno-oncology, oncology and respiratory disease. The Company has collaborations with multiple pharmaceutical companies including AbbVie, Boehringer Ingelheim, Eddingpharm, Genzyme, Merck & Co., Inc., Merck KGaA, Novartis, Novo Nordisk and Taisho Pharmaceuticals. The Company is headquartered in Ghent, Belgium. More information can be found on www.ablynx.com.

 

(Jr) Research Associate Downstream process development - TEMP 1 YEAR

Job Description

The DownStream Process (DSP) Development team (~ 20 people) within the Chemistry Manufacturing and Control (CMC) Pharmaceutical Development & Technology Department at Ablynx is looking for a (Jr) Research Associate who will be part of the team responsible for:

  • Generic purifications to deliver CMC grade Nanobody batches for all projects running in Ablynx
  • Development of DSP processes for Nanobody® Development Candidates during pre-clinical development
  • Large-scale DSP activities (purification of tens to thousands of grams), including in-house production of non-GMP DS for toxicology studies
  • DSP-related activities to support late-stage projects (e.g. PAR studies and process validation).
  • DSP platform improvement and new Technology exploration

 

Responsibilities

    • Uses state-of-the-art equipment and different types of chromatography (affinity, IEX, HIC, mixed mode) and filtration (µ-filtration and ultrafiltration TFF, depth filtration) techniques to perform generic purifications in a timely manner with eye for quality
    • Reports about the results and progress to the line manager
    • Prepares experimental reports (eLN) and meeting summaries/presentations

Profile

The candidate should:

  • Have degree B. Sc., M. Sc. (Industrial Engineer), Master in Biochemistry/ Biotechnology or equivalent
  • Have a hands-on mentality
  • Have excellent communication skills (fluent in English, written and spoken)
  • Have knowledge of Word, Powerpoint and Excel
  • Have good organizational skills
  • Have sense for initiative, quality and accuracy
  • Have the ability and desire to work in a fast-paced, dynamic environment
  • Be a team player, enthusiastic and flexible

Your application will be evaluated by the HR department of Ablynx itself. For any additional feedback regarding your application, we kindly refer you to the Ablynx HR department.


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