Ablynx is a biopharmaceutical company engaged in the development of Nanobodies®, proprietary therapeutic proteins based on single-domain antibody fragments, which combine the advantages of conventional antibody drugs with some of the features of small-molecule drugs. Ablynx is dedicated to creating new medicines which will make a real difference to society. Today, the Company has approximately 40 proprietary and partnered programmes in development in various therapeutic areas including inflammation, haematology, immuno-oncology, oncology and respiratory disease. The Company has collaborations with multiple pharmaceutical companies including AbbVie, Boehringer Ingelheim, Eddingpharm, Genzyme, Merck & Co., Inc., Merck KGaA, Novartis, Novo Nordisk and Taisho Pharmaceuticals. The Company is headquartered in Ghent, Belgium. More information can be found on www.ablynx.com.


(Jr) Research Associate Downstream process development - TEMP 1 YEAR

Job Description

The DownStream Process (DSP) Development team (~ 20 people) within the Chemistry Manufacturing and Control (CMC) Pharmaceutical Development & Technology Department at Ablynx is looking for a (Jr) Research Associate who will be part of the team responsible for:

  • Generic purifications to deliver CMC grade Nanobody batches for all projects running in Ablynx
  • Development of DSP processes for Nanobody® Development Candidates during pre-clinical development
  • Large-scale DSP activities (purification of tens to thousands of grams), including in-house production of non-GMP DS for toxicology studies
  • DSP-related activities to support late-stage projects (e.g. PAR studies and process validation).
  • DSP platform improvement and new Technology exploration



    • Uses state-of-the-art equipment and different types of chromatography (affinity, IEX, HIC, mixed mode) and filtration (µ-filtration and ultrafiltration TFF, depth filtration) techniques to perform generic purifications in a timely manner with eye for quality
    • Reports about the results and progress to the line manager
    • Prepares experimental reports (eLN) and meeting summaries/presentations


The candidate should:

  • Have degree B. Sc., M. Sc. (Industrial Engineer), Master in Biochemistry/ Biotechnology or equivalent
  • Have a hands-on mentality
  • Have excellent communication skills (fluent in English, written and spoken)
  • Have knowledge of Word, Powerpoint and Excel
  • Have good organizational skills
  • Have sense for initiative, quality and accuracy
  • Have the ability and desire to work in a fast-paced, dynamic environment
  • Be a team player, enthusiastic and flexible


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