Ablynx

Ablynx is a biopharmaceutical company focused on the discovery and development of Nanobodies®, a novel class of therapeutic proteins based on single-domain antibody fragments, for a range of serious and life-threatening human diseases. The Company, with Headquarters in Ghent, Belgium, began operations in 2001 and currently employs over 200 employees. Ablynx is developing a portfolio of Nanobody®-based therapeutic programmes in a number of major disease areas, including inflammation, thrombosis, oncology and Alzheimer’s disease. Ablynx has ongoing research collaborations and significant partnerships with several major pharmaceutical companies, including Boehringer Ingelheim, Wyeth Pharmaceuticals, Novartis and P&G Pharma.

(Sr) Research Associate Downstream process development

(Sr) Research Associate Downstream process development (CMC Pharmaceutical Development & Technology department)

Job Description

The DownStream Process (DSP) Development team (~ 20 people) within the Chemistry Manufacturing and Control (CMC) Pharmaceutical Development & Technology Department at Ablynx is looking for an experienced (Sr) Research Associate who will be part of the team responsible for:

  • Generic purifications to deliver CMC grade Nanobody batches for all projects running in Ablynx,
  • Development of DSP processes for Nanobody® Development Candidates during pre-clinical development
  • Large-scale DSP activities (purification of tens to thousands of grams), including in-house production of non-GMP DS for toxicology (Tox) studies
  • DSP-related activities to support late-stage projects (e.g. PAR studies and process validation).
  • DSP platform improvement and new Technology exploration

 

Responsibilities

  • Uses state-of-the-art equipment and different types of chromatography (affinity, IEX, HIC, mixed mode) and filtration (µ-filtration and ultrafiltration TFF, depth filtration) techniques to perform generic purifications in a timely manner with eye for quality
  • Is part of a team that, using a Design-of-experiment (Doe) approach, develops a DSP process for Nanobody® Development Candidates, which has a high process yield and which is robust, scalable and which delivers high quality Nanobody material to be transferred to a CMO of choice for GMP manufacturing of Nanobody batches for clinical studies
  • Is part of the team that performs large-scale DSP campaigns to facilitate Tech Transfers to CMO (Man-in-Plant runs) and provide non-GMP DS material for Tox studies
  • Is responsible for exploring new DSP-related technologies and improving platform work flows
  • Reports about the results and progress to the line manager, project team, project leader
  • Prepares experimental reports (eLN), meeting summaries/presentations and drafts working protocols in EnglishProfile
  •  

The candidate should:

  • Have degree B. Sc., M. Sc. Biotechnology/(Bio)chemistry/Pharmacology/Industrial engineer or equivalent with at least 2 to 5 years of experience in laboratory work
  • Have hands-on experience in purification of biologicals and preferably knowledge of DSP process development (different types of resin screening, Design-of-Experiment (DOE) approach for process development, gradient optimization, etc…)
  • Have hands-on experience in using (AKTA) chromatography and filtration equipment
  • Have excellent communication skills (fluent in English, written and spoken)
  • Have knowledge of Word, Powerpoint and Excel
  • Have proven organizational skills
  • Have good troubleshooting skills, sense for initiative, quality and accuracy
  • Have the ability and desire to work in a fast-paced, dynamic environment
  • Be a team player, enthusiastic and flexible

 

Please make sure your attached CV contains a paragraph describing your technical expertise.

Uw sollicitatie zal behandeld worden door het HR departement van Ablynx zelf. Voor alle bijkomende informatie aangaande uw kandidatuur verwijzen we u dan ook vriendelijk door naar het HR departement van Ablynx.


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