Ablynx

Ablynx is a biopharmaceutical company focused on the discovery and development of Nanobodies®, a novel class of therapeutic proteins based on single-domain antibody fragments, for a range of serious and life-threatening human diseases. The Company, with Headquarters in Ghent, Belgium, began operations in 2001 and currently employs over 200 employees. Ablynx is developing a portfolio of Nanobody®-based therapeutic programmes in a number of major disease areas, including inflammation, thrombosis, oncology and Alzheimer’s disease. Ablynx has ongoing research collaborations and significant partnerships with several major pharmaceutical companies, including Boehringer Ingelheim, Wyeth Pharmaceuticals, Novartis and P&G Pharma.

(Senior) Scientist - Team Leader CMC Analytics

The Analytics group of the CMC Pharmaceutical Development & Technology Department at Ablynx is looking for an experienced (Senior) Scientist that will be part of the analytical team responsible for non-GMP activities:

  • Formulation studies
  • In process monitoring and control
  • Method development and qualification
  • Release and stability studies
  • Characterization of the product related variants
  • In-use stability and compatibility

The successful candidate will head a team of (senior) research associates and/or (associate) scientists and will be responsible for the planning, coordination, follow-up and reporting of assigned project activities.

Key responsibilities:

 

  • Responsible for the research approach and results of an intradepartmental team within the scope of assigned project activities
  • People management: drives recruitment of team members, training, development and performance management
  • Uses state-of-the-art equipment to supervise and develop various analytical methods including (U)HPLC, UV- and fluorescence spectroscopy, capillary electrophoresis, iso-electric focusing (IEF), SDS-PAGE, DLS, DSC, MFI, MALS, osmolality and viscosity measurements, endotoxin testing, ELISA,…
  • Applies these techniques in stability studies, stress testing and the development of stable formulations
  • Applies these methods to control the quality and consistency of Nanobody productions and thereby assist in the development of a large-scale manufacturing process for a specific lead Nanobody
  • Performs physico-chemical characterization of Nanobodies, identifies product variants and investigates degradation pathways
  • Reports about the results and progress to the line manager, project team, project leader and/or external parties in a clear and concise manner. Provides strategic guidance where needed
  • Prepares high level reports, summaries, manuscripts and other documents as appropriate

Profile:

The candidate should:

  • Hold a PhD. in Biology, Biotechnology, (Bio)Chemistry, Pharmacology or equivalent
  • Have experience in physico-chemical analysis of biologicals and knowledge of different analytical techniques. Experience in Biotech/Pharma is a plus
  • Have a proven managerial experience
  • Have excellent communication skills (fluent in English, written and spoken)
  • Demonstrate proven organizational and coordination skills
  • Have sense for initiative, quality, accuracy and detail
  • Have the ability and desire to work in a fast-paced, dynamic environment
  • Be a team player, enthusiastic and flexible

The CV of the applicant should be in English, and include a paragraph specifying the technical expertise

 

Uw sollicitatie zal behandeld worden door het HR departement van Ablynx zelf. Voor alle bijkomende informatie aangaande uw kandidatuur verwijzen we u dan ook vriendelijk door naar het HR departement van Ablynx.


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