Ablynx

Ablynx is a biopharmaceutical company focused on the discovery and development of Nanobodies®, a novel class of therapeutic proteins based on single-domain antibody fragments, for a range of serious and life-threatening human diseases. The Company, with Headquarters in Ghent, Belgium, began operations in 2001 and currently employs over 200 employees. Ablynx is developing a portfolio of Nanobody®-based therapeutic programmes in a number of major disease areas, including inflammation, thrombosis, oncology and Alzheimer’s disease. Ablynx has ongoing research collaborations and significant partnerships with several major pharmaceutical companies, including Boehringer Ingelheim, Wyeth Pharmaceuticals, Novartis and P&G Pharma.

Senior Research Associate CMC Analytics

Looking for a Senior Research Associate involved in making of Nanobody® based Pharmaceutical drugs

 

Ablynx is a biopharmaceutical company dedicated to creating new antibody-based medicines called Nanobodies which will make a real difference to society. Ablynx has currently over 400 people working on the development of Nanobodies for the treatment of a wide range of diseases, including inflammation, haematology, respiratory disease, immuno-oncology and oncology.

The Analytics group of the CMC Pharmaceutical Development & Technology Department at Ablynx is looking for an experienced Research Associate that will be part of the team responsible for the in depth analysis of the quality and stability of lead Nanobodies® during pre-clinical and clinical development. A multitude of assays is being used in the team including standard techniques such as Reversed Phase, Size Exclusion and other (U)HPLC chromatography, Mass Spectrometry, UV- and fluorescence spectroscopy, capillary electrophoresis, Dynamic Light Scattering (DLS), Differential Scanning Calorimetry (DSC), Micro-Flow Imaging (MFI), Light obscuration, osmolality and viscosity measurements, endotoxin testing, Host Cell Proteins assay, …. Those techniques are applied:

  • in stability studies, stress testing and the development of stable formulations
  • to control the quality and consistency of Nanobody productions and thereby assist in the development of a large-scale manufacturing process for a specific lead Nanobody
  • to perform physico-chemical characterization of Nanobodies, identification of product variants and investigation of degradation pathways

Profile:

  • Bachelor or Master degree in life sciences (such as Degree of Professional Bachelor in Laboratory Technology or Biotechnology (Laboratory Technician A1), Bachelor or Master in Industrial Sciences (Industrial Engineer), Biochemistry, Biotechnology, Biomedical sciences or similar)
  • Hands-on mentality and comfortable with controlling high tech instrumentation
  • Able to work independently and in team, enthusiastic and self-motivated
  • Good writing and presentation skills
  • Ability and desire to work in a fast-paced, dynamic environment
  • Good sense for initiative, quality, accuracy and detail
  • Team player
  • Experience in physico-chemical analysis of proteins is an asset
  • Ability to design experiments independently, to plan and perform experiments and to prepare concise reports of the results in English.
  • Previous analytical experience (at least 5 years) in industry and with some of the above-mentioned techniques is required.
  • Knowledge of English

The CV of the applicant should be in English, and include a paragraph specifying the technical expertise.

 


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